The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2012
Filed:
Dec. 18, 2009
Erik DE Vries, Livermore, CA (US);
Louis Clark, San Francisco, CA (US);
Scott Mcvicar, Sunnyvale, CA (US);
Erika Segraves, Sunnyvale, CA (US);
Shiwei Song, Singapore, SG;
Kheng Lin Tan, Singapore, SG;
Erik De Vries, Livermore, CA (US);
Louis Clark, San Francisco, CA (US);
Scott McVicar, Sunnyvale, CA (US);
Erika Segraves, Sunnyvale, CA (US);
Shiwei Song, Singapore, SG;
Kheng Lin Tan, Singapore, SG;
Codexis, Inc., Redwood City, CA (US);
Abstract
The present disclosure provides engineered halohydrin dehalogenase (HHDH) polypeptides having improved enzyme properties as compared to the wild-type HHDH enzyme HheC and other reference engineered HHDH polypeptides. Also provided are polynucleotides encoding the engineered HHDH enzymes, host cells capable of expressing the engineered HHDH enzymes, and methods of using the engineered HHDH enzymes to synthesize a variety of chiral compounds including chiral epoxides and chiral alcohols.