The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2012
Filed:
May. 03, 2011
Michael D. Bentley, Huntsville, AL (US);
Xuan Zhao, Beijing, CN;
Xiaoming Shen, Madison, AL (US);
Lihong Guo, Beijing, CN;
Michael D. Bentley, Huntsville, AL (US);
Xuan Zhao, Beijing, CN;
Xiaoming Shen, Madison, AL (US);
Lihong Guo, Beijing, CN;
Nektar Therapeutics, San Francisco, CA (US);
Abstract
The invention provides a sterically hindered polymers and conjugates formed therefrom that comprise a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative prior to conjugation, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).