The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8183239 B1

Date of Patent:

May. 22, 2012

Filed:

Oct. 27, 2006

Substituted piperazines and piperidines as modulators of the neuropeptide y2 receptor

Applicants:

Pascal Bonaventure, San Diego, CA (US);

Nicholas I. Carruthers, Poway, CA (US);

Wenying Chai, San Diego, CA (US);

Curt A. Dvorak, San Diego, CA (US);

Jill A. Jablonowski, San Diego, CA (US);

Dale A. Rudolph, San Diego, CA (US);

Mark Seierstad, San Diego, CA (US);

Chandravadan R. Shah, San Diego, CA (US);

Devin M. Swanson, La Jolla, CA (US);

Victoria D. Wong, San Diego, CA (US);

Inventors:

Pascal Bonaventure, San Diego, CA (US);

Nicholas I. Carruthers, Poway, CA (US);

Wenying Chai, San Diego, CA (US);

Curt A. Dvorak, San Diego, CA (US);

Jill A. Jablonowski, San Diego, CA (US);

Dale A. Rudolph, San Diego, CA (US);

Mark Seierstad, San Diego, CA (US);

Chandravadan R. Shah, San Diego, CA (US);

Devin M. Swanson, La Jolla, CA (US);

Victoria D. Wong, San Diego, CA (US);

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:

Samuel M. Kais

Primary Examiner:

Emily Bernhardt

Int. Cl.

CPC ...

A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); C07D 211/34 (2006.01); C07D 211/58 (2006.01); C07D 213/56 (2006.01); C07D 295/15 (2006.01); C07D 401/04 (2006.01); A61K 31/451 (2006.01); A61K 31/454 (2006.01); C07D 401/12 (2006.01); C07D 417/12 (2006.01);

U.S. Cl.

CPC ...

Abstract

The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility. The compounds of the present invention are of the formula where Ring T is a heterocycloalkyl ring selected from the group consisting of:

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