The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2012
Filed:
Jun. 30, 2010
Bansi Lal, Mumbai, IN;
Swati Bal-tembe, Mumbai, IN;
Usha Ghosh, Mumbai, IN;
Arun Kumar Jain, Mumbai, IN;
Tulsidas More, Mumbai, IN;
Anil Ghate, Mumbai, IN;
Jacqueline Trivedi, Mumbai, IN;
Sapna Parikh, Mumbai, IN;
Bansi Lal, Mumbai, IN;
Swati Bal-Tembe, Mumbai, IN;
Usha Ghosh, Mumbai, IN;
Arun Kumar Jain, Mumbai, IN;
Tulsidas More, Mumbai, IN;
Anil Ghate, Mumbai, IN;
Jacqueline Trivedi, Mumbai, IN;
Sapna Parikh, Mumbai, IN;
Piramal Life Sciences Limited, Mumbai, IN;
Abstract
Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRR, O, NRor S(O); V is CRRor NR; W is S(O); wherein Ris H, alkyl, cycloalkyl, alkenyl or aralkyl; Ris H, alkyl, OH, ORor OCOR, and m is the integer 0, 1 or 2; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7 or R8 is guanidino or guanidinocarbonyl. These derivatives are sodium-proton exchange inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and diabetes.