The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2012
Filed:
May. 08, 2009
James E. Kipp, Wauconda, IL (US);
Joseph Chung Tak Wong, Long Grove, IL (US);
Lakshmy Nair, Vernon Hills, IL (US);
Reagan Miller, Wildwood, IL (US);
Barrett E. Rabinow, Skokie, IL (US);
James E. Kipp, Wauconda, IL (US);
Joseph Chung Tak Wong, Long Grove, IL (US);
Lakshmy Nair, Vernon Hills, IL (US);
Reagan Miller, Wildwood, IL (US);
Barrett E. Rabinow, Skokie, IL (US);
Baxter International Inc., Deerfield, IL (US);
Baxter Healthcare S.A., Glattpark (Opfikon), CH;
Abstract
Stable pharmaceutical formulations and methods of making same are provided. In a general embodiment, the present disclosure provides a method of making a stable pharmaceutical formulation comprising adding one or more vitrifying additives to an aqueous pharmaceutical solution to raise the glass transition temperature of the aqueous pharmaceutical solution. The aqueous pharmaceutical solution can be cooled to a temperature of about −50° C. to about −10° C. The vitrifying additive enhances the formation of a glass or amorphous solid of the aqueous pharmaceutical solution at cryogenic temperatures (−50 to −10° C.), and the pharmaceutical formulation can be thawed to liquid form and administered to a mammalian subject.