The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2012
Filed:
Sep. 12, 2005
James J Collins, Newton, MA (US);
Hideki Kobayashi, Yokohama, JP;
Mads Kearn, Ottawa, CA;
Michihiro Araki, Minatoku, JP;
Ari Friedland, Boston, MA (US);
Timothy Kuan-ta LU, Palo Alto, CA (US);
James J Collins, Newton, MA (US);
Hideki Kobayashi, Yokohama, JP;
Mads Kearn, Ottawa, CA;
Michihiro Araki, Minatoku, JP;
Ari Friedland, Boston, MA (US);
Timothy Kuan-Ta Lu, Palo Alto, CA (US);
Trustees of Boston University, Boston, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm degrading enzymes and proteins necessary for the phage to replicate in different naturally occurring biofilm producing bacteria. The phages of the invention allow a method of biofilm degradation by the use of one or only a few administration of the phage because the system using these phages is self perpetuating, and capable of degrading biofilm even when the concentration of bacteria within the biofilm is low.