The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2012
Filed:
Mar. 10, 2006
Manne Satyanarayana Reddy, Hyderabad, IN;
Muppa Kishore Kumar, Hyderabad, IN;
Srinivasan Thirumalai Rajan, Hyderabad, IN;
Karamala Ramasubba Reddy, Kadapa, IN;
Manne Satyanarayana Reddy, Hyderabad, IN;
Muppa Kishore Kumar, Hyderabad, IN;
Srinivasan Thirumalai Rajan, Hyderabad, IN;
Karamala Ramasubba Reddy, Kadapa, IN;
MSN Laboratories Limited, Andhra Pradesh, Hyderabad, IN;
Abstract
An improved process for the preparation of Montelukast and its pharmaceutically acceptable salts comprises of reacting (S) Benzenepropanol α-[3-[2-(7-chloro2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate compound of formula (II) with 1-(mercapto methyl)cyclo propane acetic acid or its ester or nitrile in presence of alkali or alkaline carbonates and/or alkali or alkaline earth metal alkoxide in a suitable polar aprotic solvent with or without combination of C-Calcoholic solvents and then treating with organic amine in a suitable ester and/or acetone and/or aliphatic or aromatic hydrocarbon solvents, and converting the corresponding amine salt compound of montelukast into its sodium salt compound of formula (I) using sodium ion source in methanol, without converting into montelukast free acid.