The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 15, 2012

Filed:

Jun. 27, 2007
Applicants:

Craig Lindsley, Brentwood, TN (US);

William D. Shipe, Chalfont, PA (US);

Feng Yang, Hatfield, PA (US);

Jaime Lynn Bunda, Holland, PA (US);

Inventors:

Craig Lindsley, Brentwood, TN (US);

William D. Shipe, Chalfont, PA (US);

Feng Yang, Hatfield, PA (US);

Jaime Lynn Bunda, Holland, PA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention is directed to benzyl-substituted quinolone compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of diseases in which the M1 receptor is involved.


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