The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2012
Filed:
Dec. 18, 2006
József Bódi, Budapest, HU;
János Éles, Budapest, HU;
Katalin Szöke, Budapest, HU;
Krisztina Vukics, Budapest, HU;
Tamás Gáti, Budapest, HU;
Krisztina Temesvári, Budapest, HU;
Dorottya Kiss-bartos, Albertirsa, HU;
József Bódi, Budapest, HU;
János Éles, Budapest, HU;
Katalin Szöke, Budapest, HU;
Krisztina Vukics, Budapest, HU;
Tamás Gáti, Budapest, HU;
Krisztina Temesvári, Budapest, HU;
Dorottya Kiss-Bartos, Albertirsa, HU;
Richter Gedeon Nyrt., Budapest, HU;
Abstract
A process for the production of 1-(4-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) according to the following reaction scheme: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) where the substances of the general Formulas II, IV, VI, VIII, IX, X and XI are new, Formula III is a non-isolated intermediate, R1, R2 and R3 are represented by the compounds of Formulas Va-Vd, (Va), (Vb), (Vc), (Vd) and R4 is a silyl, e.g., tert-butyl-dimethyl-silyl, tert-butyl-diphenyl-silyl group.