The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2012
Filed:
Apr. 14, 2010
Susan D. Aster, Teaneck, NJ (US);
James M. Balkovec, Martinsville, NJ (US);
Donald W. Graham, Mountainside, NJ (US);
Xin Gu, Scotch Plains, NJ (US);
Nancy J. Kevin, East Brunswick, NJ (US);
Gool F. Patel, Califon, NJ (US);
Mitree Ponpipom, Branchburg, NJ (US);
Susan D. Aster, Teaneck, NJ (US);
James M. Balkovec, Martinsville, NJ (US);
Donald W. Graham, Mountainside, NJ (US);
Xin Gu, Scotch Plains, NJ (US);
Nancy J. Kevin, East Brunswick, NJ (US);
Gool F. Patel, Califon, NJ (US);
Mitree Ponpipom, Branchburg, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
2,5-Diaryl-1,2,4-triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase Type 1 enzyme (11β-HSD-1). The compounds are useful for the treatment of diabetes, hyperglycemia, obesity, insulin resistance, atherosclerosis, dyslipidemia, hyperlipidemia, hypertension, and Metabolic Syndrome. Also disclosed are novel compounds of structural formula II which are inhibitors of 11β-HSD-1.