The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2012
Filed:
Jun. 28, 2007
Joshua Labaer, Matfield, MA (US);
Niroshan Ramachandran, Needham, MA (US);
Manuel Fuentes Garcia, Cambridge, MA (US);
Joshua Labaer, Matfield, MA (US);
Niroshan Ramachandran, Needham, MA (US);
Manuel Fuentes Garcia, Cambridge, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence and an affinity tag, and (ii) a binding agent that recognizes the affinity tag; contacting the substrate with a translation effector to thereby translate the hybrid amino acid sequence; maintaining the substrate under conditions permissive for the hybrid amino acid sequence to bind the binding agent; and removing the nucleic acid from the substrate. In one embodiment, the substrate includes a plurality of positionally-distinguishable addresses, for example, each include a different nucleic acid. The addresses can be located a regularly or irregularly spaced locations.