The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2012
Filed:
May. 26, 2009
Laird Bloom, Needham, MA (US);
Davinder Gill, Andover, MA (US);
Yulia Vugmeyster, North Reading, MA (US);
Deborah A. Young, Melrose, MA (US);
Margot O'toole, Newtonville, MA (US);
Heath M. Guay, Waltham, MA (US);
Karissa K. Adkins, Haverhill, MA (US);
Amy Arlene Weaver, North Reading, MA (US);
Sadhana Jain, West Roxbury, MA (US);
Maya Arai, Brookline, MA (US);
Laird Bloom, Needham, MA (US);
Davinder Gill, Andover, MA (US);
Yulia Vugmeyster, North Reading, MA (US);
Deborah A. Young, Melrose, MA (US);
Margot O'Toole, Newtonville, MA (US);
Heath M. Guay, Waltham, MA (US);
Karissa K. Adkins, Haverhill, MA (US);
Amy Arlene Weaver, North Reading, MA (US);
Sadhana Jain, West Roxbury, MA (US);
Maya Arai, Brookline, MA (US);
Wyeth LLC, Madison, NJ (US);
Abstract
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.