The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
Feb. 08, 2008
Thomas J. Wandless, Menlo Park, CA (US);
Laura Anne Banaszynski, New York, NY (US);
Mari Iwamoto, Stanford, CA (US);
Lystranne Alysia Maynard, Silver Spring, MD (US);
Ling-chun Chen, Fremont, CA (US);
Thomas J. Wandless, Menlo Park, CA (US);
Laura Anne Banaszynski, New York, NY (US);
Mari Iwamoto, Stanford, CA (US);
Lystranne Alysia Maynard, Silver Spring, MD (US);
Ling-chun Chen, Fremont, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Abstract
Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the fusion protein.