The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
Jun. 14, 2004
David B. Weiner, Merion, PA (US);
Michele Kutzler, Souderton, PA (US);
Andrew Y. Choo, Boston, MA (US);
Joo-sung Yang, Suwon, KR;
Jean D. Boyer, Haddonfield, NJ (US);
David B. Weiner, Merion, PA (US);
Michele Kutzler, Souderton, PA (US);
Andrew Y. Choo, Boston, MA (US);
Joo-Sung Yang, Suwon, KR;
Jean D. Boyer, Haddonfield, NJ (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Fusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising an IgE signal peptide linked to non-IgE protein sequences are disclosed. Vectors comprising such nucleic acid molecules; and to host cells comprising such vectors are disclosed as well as recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed. The immunomodulatory effect following delivery of IL-15 and CD40L, with or without immunogens, is disclosed as are various nucleic acid molecules and compositions thereof used for delivering such proteins and methods of using such compositions.