The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
Apr. 20, 2007
Christina Furebring, Lund, SE;
Johannes A. G. Van Strijp, Odijk, NL;
Petrus J. A. Haas, Utrecht, NL;
Anna Rosen, S. Sandby, SE;
Karin Haraldsson, Lund, SE;
Erika Gustafsson, Lund, SE;
Lena Schultz, Bethesda, MD (US);
Cornelis P. M. Van Kessel, Bunnik, NL;
Christina Furebring, Lund, SE;
Johannes A. G. Van Strijp, Odijk, NL;
Petrus J. A. Haas, Utrecht, NL;
Anna Rosen, S. Sandby, SE;
Karin Haraldsson, Lund, SE;
Erika Gustafsson, Lund, SE;
Lena Schultz, Bethesda, MD (US);
Cornelis P. M. Van Kessel, Bunnik, NL;
Alligator Bioscience AB, Lund, SE;
Abstract
The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of('CHIPS'), the polypeptide comprising a variant of the amino acid sequence of SEQ ID NO:1. Preferably, the polypeptide is a CHIPS variant wherein one or more of the following amino acids is modified: N31, S32, G33, L34, P35, K40, D42, R46, Y48, K50, G52, T53, K54, N55, S56, A57, Q58, K61, E67, K69, L76, N77, P79, D83, L90, K92, K100, K101, S104, K105, S107, Y108, N111 and G112. In a preferred embodiment, the polypeptide is less immunogenic hi humans than the wildtype CHIPS protein. The invention further provides methods of making and using such variant CHIPS polypeptides.