The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
Apr. 10, 2006
Masaaki Matsuoka, Tokyo, JP;
Ikuo Nishimoto, Tokyo, JP;
Tomo Nishimoto, Legal Representative, Ichikawa, JP;
Sadakazu Aiso, Tokyo, JP;
Masaaki Matsuoka, Tokyo, JP;
Ikuo Nishimoto, Tokyo, JP;
Tomo Nishimoto, legal representative, Ichikawa, JP;
Sadakazu Aiso, Tokyo, JP;
Keio Univeristy, Tokyo, JP;
Abstract
One aspect of the present invention is directed to search receptors based on the information of HN signaling pathways in order to find Humanin receptor or Humanin-like polypeptide receptor (HNR), and to reveal a mechanism of promoting or suppressing the intracellular signal transduction for neuroprotecting activity of HN and identify a compound involved in the mechanism. The aspect of the invention is directed to a method for screening of HNR agonist and HNR antagonist, to utilize the screened compound in development of a drug for the treatment of neurodegenerative disease, and to provide an assay system of AD neuronal cell death, and to provide methods for the compulsory expression of HNR gene or knocking-out of intracellular genes.