The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
Jul. 16, 2008
Applicants:
Ming-kuan HU, Taipei, TW;
Yung-feng Liao, Taipei, TW;
Inventors:
Ming-Kuan Hu, Taipei, TW;
Yung-Feng Liao, Taipei, TW;
Assignee:
National Defense Medical Center, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 217/04 (2006.01); A61K 31/472 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention provides a type of novel 1,2,3,4-tetrahydroisoquinoline derivatives with a structure of formula (I): wherein R1 represents propargyl or cyclopropylmethyl; wherein R2 represents N-ethyl-N-methylamino, 1-Pyrrolidyl, 1-Piperidinyl, or 1-Morpholinyl. The invention provides further a process for preparing said derivatives and a pharmaceutical composition containing the same. Said derivatives can be used to modulate the proteolytic process of amyloid precursor proteins (APP), and provides further novel compounds useful for treating Alzheimer's disease (AD).