The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
May. 02, 2005
Applicants:
David Chauvier, Chatillon, FR;
Richard Casimir, Bischeim, FR;
Etienne Jacotot, Paris, FR;
Dominique Rebouillat, Paris, FR;
Inventors:
David Chauvier, Chatillon, FR;
Richard Casimir, Bischeim, FR;
Etienne Jacotot, Paris, FR;
Dominique Rebouillat, Paris, FR;
Assignee:
Chiesi Farmaceutici S.p.A., Parma, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2006.01); A61K 38/55 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention relates to selective new caspase-2 inhibitors that recognize caspase-2 and prevent and block its activity based on the following backbone: 2-Quinolinylcarbonyl-L-Valinyl-L-Aspartyl (methyl ester)-L-Valinyl-L-Alanyl-L-Aspartyl (methyl ester) 2,6-difluorophenyl ester SEQ ID NO:1) and derivatives thereof, SEQ ID NO:1 corresponding to formulae Ia or Ib. Application of the inhibitors for preventing and treating diseases involving caspase-2.