The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
Oct. 10, 2008
Christoph Rosenbohm, Birkerod, DK;
Lene Sonderbye Kjaerulff, Skaevinge, DK;
Majken Westergaard, Birkerod, DK;
Margit Wissenbach, Fredensborg, DK;
Jens BO Hansen, Vaerlose, DK;
Marlene Asklund, Frederiksberg C, DK;
Christoph Rosenbohm, Birkerod, DK;
Lene Sonderbye Kjaerulff, Skaevinge, DK;
Majken Westergaard, Birkerod, DK;
Margit Wissenbach, Fredensborg, DK;
Jens Bo Hansen, Vaerlose, DK;
Marlene Asklund, Frederiksberg C, DK;
Santaris Pharma A/S, Hersholm, DK;
Enzon Pharmaceuticals, Inc., Piscataway, NJ (US);
Abstract
The present disclosure concerns LNA oligonucleotides having a (sub)sequence of the general formula 5'-()(T)CAtccatggCA()(c)-3′, and preferably of the general formula 5′-TCAatccatggCAc-3′, wherein capital letters designate an LNA nucleotide analogue selected from β-D-oxy-LNA, β-D-thio-LNA, β-D-amino-LNA and α-L-oxy-LNA, small letters designate a deoxynucleotide, and underline designates either an LNA nucleotide analogue as defined above or a deoxynucleotide. Such LNA oligonucleotides exhibit surprisingly good properties with respect to inhibition of the expression of Survivin by means of an anti-sense mechanism, and thereby lead to reduction or inhibition of tumor development in vivo. The LNA oligonucleotides are superior to other LNA oligonucleotides targeting Surviving mRNA measured by functional read outs such as apoptosis induction and proliferation inhibition, and is potent in down-regulating Survivin mRNA and protein in transfected cancer cell lines, and induce apoptosis in combination with Taxol superior compared to other LNA oligonucleotides.