The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
Jan. 14, 2011
Bruno Dumas, Alfortville, FR;
Gilles Cauet, Griesheim sur Souffel, FR;
Eric Degryse, Crosne, FR;
Tilman Achstetter, Bremen, DE;
Bruno Dumas, Alfortville, FR;
Gilles Cauet, Griesheim sur Souffel, FR;
Eric Degryse, Crosne, FR;
Tilman Achstetter, Bremen, DE;
Aventis Pharma S.A., Antony, FR;
Abstract
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having a reduced 20αHSD type activity, in particular by modifying the GCY1 and/or YPR1 genes. The yeast strains of the invention make it possible to improve the efficiency of the synthesis or to increase the selectivity or the yields of the method, as well as the quality of the final product. The strains, methods and compounds of the invention are useful in the search for, the development and the production of products with therapeutic or prophylactic activity, in humans or animals, in particular of steroidal derivatives.