The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
Jun. 27, 2008
Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
Péter Gál, Budapest, HU;
Péter Závodszky, Budapest, HU;
Géza Ambrus-aikelin, Keszthely, HU;
József Kardos, Budapest, HU;
Péter Gál, Budapest, HU;
Péter Závodszky, Budapest, HU;
Géza Ambrus-Aikelin, Keszthely, HU;
József Kardos, Budapest, HU;
TargetEx Kft., Dunakeszi, HU;
Abstract
The invention relates to unglycosylated folded C-terminal fragments of a multidomain serine protease of the complement cascade obtainable by expression in a bacterial host, wherein said serine protease is capable of binding a recognition molecule of the complement cascade, e.g. C1 or MBL. The invention also relates to methods and bacterial expression vectors for the preparation of said fragments, uses of said fragments for raising antibodies and screening substrates or inhibitors of said serine proteases and uses of the fragments in research and treatment of complement related disorders. The invention also relates to assay methods for assessing MASP-1 and MASP-2 levels in a sample of biological origin. The invention provides for research tools, assays and diagnostic kits useful in complement research and research and diagnosis of complement related disorders.