The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2012
Filed:
Oct. 29, 2010
Arkadij M. Elizarov, Woodland Hills, CA (US);
Carroll Edward Ball, Los Angeles, CA (US);
Jianzhong Zhang, Brea, CA (US);
Hartmuth C. Kolb, Playa Del Rey, CA (US);
R. Michael Van Dam, Los Angeles, CA (US);
Lawrence Diener, Long Beach, CA (US);
Sean Ford, Oceanside, CA (US);
Reza Miraghaie, Culver City, CA (US);
Arkadij M. Elizarov, Woodland Hills, CA (US);
Carroll Edward Ball, Los Angeles, CA (US);
Jianzhong Zhang, Brea, CA (US);
Hartmuth C. Kolb, Playa Del Rey, CA (US);
R. Michael Van Dam, Los Angeles, CA (US);
Lawrence Diener, Long Beach, CA (US);
Sean Ford, Oceanside, CA (US);
Reza Miraghaie, Culver City, CA (US);
Siemens Medical Solutions USA, Inc., Malvern, PA (US);
Abstract
Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.