The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 01, 2012
Filed:
Nov. 15, 2007
Jonathan Bayldon Baell, Bundoora, AU;
Guillaume Laurent Lessene, Coburg, AU;
Brad Edmund Sleebs, Reservoir, AU;
Wayne J. Fairbrother, Burlingame, CA (US);
John A. Flygare, Burlingame, CA (US);
Michael F. T. Koehler, Palo Alto, CA (US);
Jonathan Bayldon Baell, Bundoora, AU;
Guillaume Laurent Lessene, Coburg, AU;
Brad Edmund Sleebs, Reservoir, AU;
Wayne J. Fairbrother, Burlingame, CA (US);
John A. Flygare, Burlingame, CA (US);
Michael F. T. Koehler, Palo Alto, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mimic the biological activity of BH3-only proteins and are capable of binding to and neutralizing pro-survival Bcl-2 proteins: wherein A, A, B, B, B, X, Z, R, R, Rand t are as described herein. The invention also relates to processes of preparing the benzenesulfonamide compounds that mimic portions of peptides and proteins, and to the use of such compounds in the regulation of cell death and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death.