The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2012
Filed:
May. 23, 2008
Wenge Zhong, Thousand Oaks, CA (US);
Stephen Hitchcock, Westlake Village, CA (US);
Vinod F. Patel, Acton, MA (US);
Michael Croghan, Thousand Oaks, CA (US);
Thomas Dineen, Somerville, MA (US);
Scott Harried, Woodland Hills, CA (US);
Daniel Horne, Thousand Oaks, CA (US);
Ted Judd, Simi Valley, CA (US);
Matthew Kaller, Ventura, CA (US);
Charles Kreiman, Watertown, MA (US);
Patricia Lopez, West Hills, CA (US);
Holger Monenschein, Camarillo, CA (US);
Thomas Nguyen, Thousand Oaks, CA (US);
Matthew Weiss, Boston, MA (US);
Qiufen Xue, Newbury Park, CA (US);
Bryant Yang, Simi Valley, CA (US);
Wenge Zhong, Thousand Oaks, CA (US);
Stephen Hitchcock, Westlake Village, CA (US);
Vinod F. Patel, Acton, MA (US);
Michael Croghan, Thousand Oaks, CA (US);
Thomas Dineen, Somerville, MA (US);
Scott Harried, Woodland Hills, CA (US);
Daniel Horne, Thousand Oaks, CA (US);
Ted Judd, Simi Valley, CA (US);
Matthew Kaller, Ventura, CA (US);
Charles Kreiman, Watertown, MA (US);
Patricia Lopez, West Hills, CA (US);
Holger Monenschein, Camarillo, CA (US);
Thomas Nguyen, Thousand Oaks, CA (US);
Matthew Weiss, Boston, MA (US);
Qiufen Xue, Newbury Park, CA (US);
Bryant Yang, Simi Valley, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I or Formula II wherein R, R, R, B, R, R, Rand W of Formula I, and R, R, R, R, R, R, R, R, A, A, A, A, W, X, Z, m and n of Formula II are defined herein. The invention also provides compounds of Formula III, sub-Formulas II-A-II-D, sub-Formulas III-A-III-D and Formula IV. The invention further includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, AD, cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions. The invention also comprises further embodiments of Formulas I, II, III, IV and sub-formulas thereof, intermediates and processes useful for the preparation of compounds of Formulas I, II, III, IV and sub-formulas thereof.