The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2012
Filed:
Apr. 04, 2005
Kenneth W. Carpenter, San Diego, CA (US);
William G. Turnell, San Diego, CA (US);
Kristin M. Defife, San Diego, CA (US);
Kathryn A. Grako, San Diego, CA (US);
Kenneth W. Carpenter, San Diego, CA (US);
William G. Turnell, San Diego, CA (US);
Kristin M. DeFife, San Diego, CA (US);
Kathryn A. Grako, San Diego, CA (US);
Other;
Abstract
The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium in Type II diabetics. In one embodiment, the bioligand is a peptide that specifically binds to an integrin receptor on PECs. The invention also provides methods for using such vascular stents and other implantable devices to promote vascular healing in Type II diabetics, for example following mechanical intervention.