The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2012
Filed:
Jul. 10, 2009
Claudio Gianluca Pozzoli, Monza, IT;
Franco Malanga, San Guiliano Milanese, IT;
Vincenzo Redaelli, Mariano Comense, IT;
Claudio Gianluca Pozzoli, Monza, IT;
Franco Malanga, San Guiliano Milanese, IT;
Vincenzo Redaelli, Mariano Comense, IT;
Farmabios S.p.A., Gropello Cairoli (PV), IT;
Abstract
A process for the preparation of neuromuscular blocking agents with isoquinoline structure, such as atracurium besylate, doxacurium chloride, mivacurium chloride and gantacurium chloride, by chromatographic purification of their mixtures of isomers using a silica modified by treatment with a tertiary amine of formula NRRRor a corresponding quaternary ammonium compound NRRRRXwherein R, R, Rand R, the same or different, are linear or branched C-Calkyl groups or —CH—Ar groups or two among R, R, Rand Rform a 5- or 6-membered cycle, optionally substituted with a —CH—Ar group or condensed with an Ar group, Ar being an aryl optionally substituted with one or more electrodonating groups, and Xbeing a suitable anion, is described.