The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2012
Filed:
Mar. 26, 2009
Jane Far-jine Djung, Furlong, PA (US);
Adam Golebiowski, Madison, CT (US);
Jack A. Hunter, Loveland, OH (US);
Gary P. Schrum, Maineville, OH (US);
Jane Far-Jine Djung, Furlong, PA (US);
Adam Golebiowski, Madison, CT (US);
Jack A. Hunter, Loveland, OH (US);
Gary P. Schrum, Maineville, OH (US);
Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;
Abstract
The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimidines inhibitors having the structure shown below: wherein R and Rare as defined herein. The 2-arylamino-4 -(aminoalkylene)aminopyrimidines inhibit Protein Kinase C-alpha (PKC-α). The PKC-α inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4 -(aminoalkylene)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.