The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2012
Filed:
May. 12, 2008
Yang Liu, Ann Arbor, MI (US);
Pan Zheng, Ann Arbor, MI (US);
Xing Chang, Ann Arbor, MI (US);
Lizhong Wang, Ann Arbor, MI (US);
Runhua Liu, Ann Arbor, MI (US);
Yin Wang, Ann Arbor, MI (US);
Yan Liu, Ann Arbor, MI (US);
Tao Zuo, Columbus, OH (US);
Yang Liu, Ann Arbor, MI (US);
Pan Zheng, Ann Arbor, MI (US);
Xing Chang, Ann Arbor, MI (US);
Lizhong Wang, Ann Arbor, MI (US);
Runhua Liu, Ann Arbor, MI (US);
Yin Wang, Ann Arbor, MI (US);
Yan Liu, Ann Arbor, MI (US);
Tao Zuo, Columbus, OH (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a FOXP3 protein or FOXP3 gene in a test sample to that of a normal or prior sample. A method of screening a test compound for anti-cancer activity comprising administering to cells the test compound and measuring FOXP3 protein or FOXP3 gene expression is moreover provided herein.