The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2012
Filed:
May. 06, 2009
Richard A. Gross, New York, NY (US);
Wenhua LU, Brooklyn, NY (US);
Jon Ness, Redwood City, CA (US);
Jeremy Minshull, Los Altos, CA (US);
Richard A. Gross, New York, NY (US);
Wenhua Lu, Brooklyn, NY (US);
Jon Ness, Redwood City, CA (US);
Jeremy Minshull, Los Altos, CA (US);
DNA Twopointo, Inc., Menlo Park, CA (US);
Abstract
A substantially purehost cell for the production of a α-carboxyl-ω-hydroxy fatty acid having a carbon chain length in the range from C6 to C22, a α,ω-dicarboxylic fatty acid having a carbon chain length in the range from C6 to C22, or mixtures thereof, is provided. Thehost cell is characterized by a first genetic modification class and a second genetic modification class. The first genetic modification class comprises one or more genetic modifications that disrupt the peroxisomal β-oxidation pathway. The second genetic modification class comprises one or more genetic modifications that collectively or individually disrupt at least one gene selected from the group consisting of a CYP52A type cytochrome P450, a fatty alcohol oxidase, and an alcohol dehydrogenase.