The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2012
Filed:
Oct. 10, 2003
Shuji Ozaki, Tokushima, JP;
Masahiro Abe, Tokushima, JP;
Masayuki Tsuchiya, Shizuoka, JP;
Naoki Kimura, Shizuoka, JP;
Shigeto Kawai, Shizuoka, JP;
Shuji Ozaki, Tokushima, JP;
Masahiro Abe, Tokushima, JP;
Masayuki Tsuchiya, Shizuoka, JP;
Naoki Kimura, Shizuoka, JP;
Shigeto Kawai, Shizuoka, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Other;
Abstract
To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. The results suggested that the 2D7 antigen is an HLA class I molecule. Based on this finding, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.