The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 17, 2012
Filed:
Feb. 11, 2008
Applicants:
Thomas Wisniewski, Staten Island, NY (US);
Jaeki Min, Marietta, GA (US);
Qian LI, Frederick, MD (US);
Young-tae Chang, Singapore, SG;
Inventors:
Thomas Wisniewski, Staten Island, NY (US);
Jaeki Min, Marietta, GA (US);
Qian Li, Frederick, MD (US);
Young-Tae Chang, Singapore, SG;
Assignee:
New York University, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 1/30 (2006.01); C07D 453/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions.