The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2012
Filed:
Mar. 08, 2010
Christopher Dobson, Cambridgeshire, GB;
Fabrizio Chiti, Scandicci, IT;
Jesus Zurdo, Cambridgeshire, GB;
Kateri Hayashi Dubay, Berkeley, CA (US);
Michele Vendruscolo, Cambridgeshire, GB;
Christopher Dobson, Cambridgeshire, GB;
Fabrizio Chiti, Scandicci, IT;
Jesus Zurdo, Cambridgeshire, GB;
Kateri Hayashi DuBay, Berkeley, CA (US);
Michele Vendruscolo, Cambridgeshire, GB;
Abstract
A method of determining aggregation rate data predicting an aggregation rate of a polypeptide defined by an amino acid sequence, the method comprising determining a hydrophobicity value, a charge value, and at least one shape propensity value for said sequence; identifying one or more aggregation-influencing patterns within said sequence; determining a pattern value for the sequence responsive to said identifying; and determining said aggregation rate data by determining a weighted combination of said hydrophobicity value, said charge value, said at least one shape propensity value, said pattern value and at least one factor extrinsic to said amino acid sequence.