The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2012
Filed:
Jun. 20, 2008
Kenneth A. Jacobson, Silver Spring, MD (US);
Yoonkyung Kim, Seoul, KR;
Athena Klutz, Adelphi, MD (US);
Beatrice Hechler, Strasbourg, FR;
Christian Gachet, Lalaye, FR;
Kenneth A. Jacobson, Silver Spring, MD (US);
Yoonkyung Kim, Seoul, KR;
Athena Klutz, Adelphi, MD (US);
Beatrice Hechler, Strasbourg, FR;
Christian Gachet, Lalaye, FR;
The United States of America as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Inserm, Paris, FR;
Abstract
Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an Aadenosine receptor agonist having a purine nucleoside moiety and a functional group at the Nposition of the purine nucleoside moiety, wherein the functional group has the formula (I): NH—Ar—CH—C(═O)NH—R(I), wherein Arand Ras defined herein. Also disclosed are pharmaceutical compositions, methods of treating various diseases, and a diagnostic method employing such conjugates.