The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2012
Filed:
May. 28, 2010
Stephen J. Shuttleworth, Slough, GB;
Adrian J. Folkes, Slough, GB;
Irina S. Chuckowree, Slough, GB;
Nan Chi Wan, Slough, GB;
Timothy C. Hancox, Slough, GB;
Stewart J. Baker, Slough, GB;
Sukhjit Sohal, Slough, GB;
Mohammed A. Latif, Slough, GB;
Stephen J. Shuttleworth, Slough, GB;
Adrian J. Folkes, Slough, GB;
Irina S. Chuckowree, Slough, GB;
Nan Chi Wan, Slough, GB;
Timothy C. Hancox, Slough, GB;
Stewart J. Baker, Slough, GB;
Sukhjit Sohal, Slough, GB;
Mohammed A. Latif, Slough, GB;
F. Hoffmann-La Roche AG, Basel, CH;
Abstract
Fused pyrimidines of formula (I): wherein R-R, A and n have any of the values described in the specification; and pharmaceutically acceptable salts thereof; have activity as inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behavior associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.