The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2012
Filed:
Jun. 08, 2009
Said M. Sebti, Tampa, FL (US);
Andrew D. Hamilton, Guilford, CT (US);
James Turkson, Orlando, FL (US);
Richard Jove, Glendora, CA (US);
Said M. Sebti, Tampa, FL (US);
Andrew D. Hamilton, Guilford, CT (US);
James Turkson, Orlando, FL (US);
Richard Jove, Glendora, CA (US);
University of South Florida, Tampa, FL (US);
Yale University, New Haven, CT (US);
Abstract
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display selective inhibition of specific STAT isoform homo-dimerization. The peptidomimetic probes of STAT1 function, described herein, provide the means to preferentially inhibit STAT1 over STAT3 through the exploration of the C-terminus.