The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2012
Filed:
Feb. 12, 2009
Applicants:
Sung Wan Kim, Salt Lake City, UT (US);
Tae-il Kim, Salt Lake City, UT (US);
Inventors:
Sung Wan Kim, Salt Lake City, UT (US);
Tae-il Kim, Salt Lake City, UT (US);
Assignee:
University of Utah, Salt Lake City, UT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/14 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
An arginine-grafted bioreducible poly(disulfide amine) ('ABP') as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with plasmid DNA. ABP is biodegraded under reducing conditions, such as the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity.