The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2012
Filed:
May. 04, 2006
Alan Hornsby Davidson, Abingdon, GB;
Stephen John Davies, Abingdon, GB;
David Festus Charles Moffat, Abingdon, GB;
Alan Hornsby Davidson, Abingdon, GB;
Stephen John Davies, Abingdon, GB;
David Festus Charles Moffat, Abingdon, GB;
Chroma Therapeutics Ltd., , GB;
Abstract
Compounds of formula (IA) or (IB), are inhibitors of aurora kinase activity: Formula (IA), (IB) wherein -L1Y1-[CH2]z- is a linker radical wherein Y, Land z are as defined in the claims; Ris C-Calkoxy, hydrogen or halo; W represents a bond, —CH—, —O—, —S—, —S(═O)—, or —NR— where Ris hydrogen or C-Calkyl; Q is ═N—, ═CH— or ═C(X)— wherein Xis cyano, cyclopropyl or halo; linker radicals Lare as defined in the claims; R is a radical of formula (X) or (Y): wherein Ris a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; Ris hydrogen; or optionally substituted C-Calkyl, C-Ccycloalkyl, aryl, aryl(C-Calkyl)-, heteroaryl, heteroaryl(C-Calkyl)-, —(C═O)R, —(C═O)OR, or —(C═O)NRwherein Ris hydrogen or optionally substituted (C-C)alkyl, C-Ccycloalkyl, aryl, aryl(C-Calkyl)-, heteroaryl, or heteroaryl(C-Calkyl)-; Ris hydrogen or optionally substituted C-Calkyl; and D is a mono-cyclic heterocyclic ring of 5 or 6 ring atoms.