Modulators of cb1 receptors

Abstract

Compounds of formula (I) suppress the normal signalling activity CB1 receptors, and are thus useful in the treatment of diseases or conditions which are mediated by CB1 receptor signalling activity, such as treatment of obesity and overweight, prevention of weigh gain, treatment of diseases and conditions directly or indirectly associated with obesity and overweight: wherein Ais hydrogen, —COOH, or tetrazolyl; p and q are independently 0 or 1; A3 is phenyl or cycloalkyl, either of which is optionally substituted with Rand/or R; Rand Rare independently —R, —CN, —F, —Cl, —Br, —OR, —NRR, —NRCOR, —NRSOR, —COR, —SR, —SOR, or —SOR; Ris C-Calkyl, cycloalkyl, —CFor —NRR; Rand Rare independently hydrogen, C-Calkyl or cycloalkyl; Ris hydrogen, C-Calkyl, C-Calkoxy, C-Calkoxy(C-Calkyl)-, cycloalkyl, or fully or partially fluorinated C-Calkyl; R(i) a bond; (ii) a divalent radical of formula —(CH)B(CH)wherein a and b are independently O, 1, 2 or 3 provided that a+b is 1, 2 or 3, and Bis —CO—, -0-, —S—, —SO—, —SO—, —CH—, —CHCH—, —CHOH— or —NR—; or (iii) a divalent radical selected from —C(R)(R)—*, —C(R)(R)—O—*, —C(R)(R)CH—*, —C(R)(R)CH—O—*, —CHC(R)(R)—*, —CHC(R)(R)—O—*, —CH—O—C(R)(R)—* and —C(R)(R)—O—CH—*, wherein the bond indicated by an asterisk is attached to the pyrazole ring; Z is as defined in the specification; Ris hydrogen and Ris (C-C)alkyl or —OH; or Rand Rare both (C-C)alkyl; or Rand Rtaken together with the carbon atom to which they are attached form a (C-C)cycloalkyl ring.