The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2012
Filed:
Feb. 08, 2011
Sek Chung Fung, Houston, TX (US);
Kang LI, San Diego, CA (US);
Yucheng LI, San Diego, CA (US);
Sanjaya Singh, Sandy Hook, CT (US);
Bin-bing Stephen Zhou, Ho Hokus, NJ (US);
Sek Chung Fung, Houston, TX (US);
Kang Li, San Diego, CA (US);
Yucheng Li, San Diego, CA (US);
Sanjaya Singh, Sandy Hook, CT (US);
Bin-Bing Stephen Zhou, Ho Hokus, NJ (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.