The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2012
Filed:
Mar. 14, 2008
Applicants:
Harmit Vora, South San Francisco, CA (US);
James Mcintire, Castro Valley, CA (US);
Pawan Kumar, Mountain View, CA (US);
Chaitan Khosla, Palo Alto, CA (US);
Inventors:
Harmit Vora, South San Francisco, CA (US);
James McIntire, Castro Valley, CA (US);
Pawan Kumar, Mountain View, CA (US);
Chaitan Khosla, Palo Alto, CA (US);
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Alvine Pharmaceuticals, Inc., San Carlos, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/09 (2006.01); C12N 15/29 (2006.01); C12N 15/57 (2006.01); C12N 9/50 (2006.01); C07K 1/14 (2006.01); C07K 1/22 (2006.01);
U.S. Cl.
CPC ...
Abstract
Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization to yield a stable product.