The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2012
Filed:
Sep. 10, 2007
Solomon H. Snyder, Baltimore, MD (US);
Alex Huang, Baltimore, MD (US);
Cory Teuscher, South Burlington, VT (US);
Sangwon Kim, Baltimore, MD (US);
Solomon H. Snyder, Baltimore, MD (US);
Alex Huang, Baltimore, MD (US);
Cory Teuscher, South Burlington, VT (US);
Sangwon Kim, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
The University of Vermont College of Medicine, Burlington, VT (US);
Abstract
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that orexigenic AAPDs potently and selectively activate hypothalamic AMP kinase (AMPK), an action abolished in mice with deletion of histamine H1 receptors. These findings afford a means of developing better therapeutic agents and provide insight into the hypothalamic regulation of food intake.