The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2012
Filed:
May. 20, 2009
YE Fang, Painted Post, NY (US);
Ann M. Ferrie, Painted Post, NY (US);
Norman H. Fontaine, Painted Post, NY (US);
Joydeep Lahiri, Painted Post, NY (US);
Po Ki Yuen, Corning, NY (US);
Ye Fang, Painted Post, NY (US);
Ann M. Ferrie, Painted Post, NY (US);
Norman H. Fontaine, Painted Post, NY (US);
Joydeep Lahiri, Painted Post, NY (US);
Po Ki Yuen, Corning, NY (US);
Corning Incorporated, Corning, NY (US);
Abstract
The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.