The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 03, 2012

Filed:

Aug. 13, 2004
Applicants:

Francis Joseph Carr, Balmedie, GB;

Stephen Williams, Alford, GB;

Stephen D. Gillies, Carlisle, MA (US);

Inventors:

Francis Joseph Carr, Balmedie, GB;

Stephen Williams, Alford, GB;

Stephen D. Gillies, Carlisle, MA (US);

Assignee:

Merck Patent GmbH, Darmstadt, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 19/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
Abstract

A CD20-binding polypeptide composition comprising a combination of a modified heavy chain variable region polypeptide and a modified light chain variable region polypeptide. The combination can be (a) a modified 2B8 antibody heavy chain variable region polypeptide of SEQ ID NO: 48; and a modified 2B8 antibody light chain variable region polypeptide of SEQ ID NO: 49; or (b) a modified Leu16 antibody heavy chain variable region polypeptide of SEQ ID NO: 50; and a modified Leu16 antibody light chain variable region polypeptide of SEQ ID NO: 51.


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