The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2012
Filed:
Sep. 14, 2009
Kandasamy Hariharan, San Diego, CA (US);
Scott Glaser, San Diego, CA (US);
Ellen Garber, Cambridge, MA (US);
Christilyn Graff, Cambridge, MA (US);
Christopher L. Reyes, San Diego, CA (US);
Stephen Demarest, San Diego, CA (US);
Kandasamy Hariharan, San Diego, CA (US);
Scott Glaser, San Diego, CA (US);
Ellen Garber, Cambridge, MA (US);
Christilyn Graff, Cambridge, MA (US);
Christopher L. Reyes, San Diego, CA (US);
Stephen Demarest, San Diego, CA (US);
Biogen Idec MA Inc., Cambridge, MA (US);
Abstract
The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.