The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2012
Filed:
Sep. 18, 2000
John C. Bell, Ontario, CA;
Nahum Sonenberg, Quebec, CA;
David F. Stojdl, Ontario, CA;
Earl G. Brown, Ontario, CA;
Harold L. Atkins, Ontario, CA;
Ricardo M. Marius, Ontario, CA;
Brian D. Lichty, Ontario, CA;
Shane B. Knowles, Ontario, CA;
John C. Bell, Ontario, CA;
Nahum Sonenberg, Quebec, CA;
David F. Stojdl, Ontario, CA;
Earl G. Brown, Ontario, CA;
Harold L. Atkins, Ontario, CA;
Ricardo M. Marius, Ontario, CA;
Brian D. Lichty, Ontario, CA;
Shane B. Knowles, Ontario, CA;
Wellstat Biologics Corporation, Gaithersburg, MD (US);
Abstract
The present invention is directed to a method of reducing the viability of a tumor cell involving administering a virus that is not a common human pathogen to the tumor cell. Preferably, the virus exhibits differential susceptibility, in that normal cells are not affected by the virus. This differential susceptibility is more pronounced in the presence of interferon. The tumor cell is characterized by having low levels, or no, PKR activity, or as being PKR−/−, STAT1−/− or both PKR−/− and STAT1−/−. The virus is selected from the group consisting of Rhabdovirus and picornavirus, and preferably is vesicular stomatitis virus (VSV) or a derivative thereof.