The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2012
Filed:
Jan. 10, 2008
Svetoslav S. Bratovanov, Ancaster, CA;
Elena Bejan, Brantford, CA;
David A. Stradiotto, Brantford, CA;
Abbulu Kante, Brantford, CA;
Zhi-xian Wang, Tianjin, CN;
Stephen E. Horne, Burlington, CA;
Svetoslav S. Bratovanov, Ancaster, CA;
Elena Bejan, Brantford, CA;
David A. Stradiotto, Brantford, CA;
Abbulu Kante, Brantford, CA;
Zhi-Xian Wang, Tianjin, CN;
Stephen E. Horne, Burlington, CA;
Apotex Pharmachem Inc., Brantford, CA;
Abstract
An industrially acceptable process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3')quiniclidine from a cis/trans mixture of isomers. Treatment of the mixture with an organic sulfonic acid generates a less soluble acid addition salt that is enriched in the cis-isomer. Recrystallization or pulping using various organic solvents allows for enrichment of the cis-isomer by filtration. These new sulfonic acid salts of the cis-isomer of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine prepared according to the present invention could be further converted into the hydrochloride salt by any known procedures such as treatment with a base and then hydrochloric acid salt formation or exchange of the sulfonic acid salt with hydrochloric acid.