The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2012
Filed:
Feb. 15, 2010
Marcelis Van Der Stelt, Oss, NL;
Joseph Maria Gerardus Barbara Cals, Oss, NL;
Johannes Petrus Gerardus Klomp, Oss, NL;
Marcelis van der Stelt, Oss, NL;
Joseph Maria Gerardus Barbara Cals, Oss, NL;
Johannes Petrus Gerardus Klomp, Oss, NL;
MSD OSS B.V., Oss, NL;
Abstract
The invention relates to 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivative having the general Formula I wherein Ris H, (C)alkyl (optionally substituted with oxo, (C)alkyloxy, (C)alkyloxycarbonyl, halogen or CN), (C)cycloalkyl or (C)cycloalkyl(C)alkyl, each cycloalkyl ring optionally comprising a heteroatom selected from O and S; Rand Rare independently H or (C)alkyl; or Rand Rform together with the carbon atom to which they are bound a (C)cycloalkyl group; Ris H or 1 to 3 F substituents; Ris H or 1 to 4 F substituents; Rand Rare independently H or F; X represents R, OR, NRR, Ris (C)cycloalkyl optionally comprising a heteroatom selected from O, S, SO and SO; Ris H or (C)alkyl; Rrepresents 1-3 substituents independently selected from H, (C)alkyl, halogen, oxo, CN and CF; Y is CF, O, S, SO or SO; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives in the treatment of pain such as for example peri-operative pain, chronic pain, neuropathic pain, cancer pain and pain and spasticity associated with multiple sclerosis.