The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 27, 2012
Filed:
Oct. 06, 2005
Alan Ashworth, London, GB;
Stephen Jackson, Cambridge, GB;
Niall Martin, Cambridge, GB;
Graeme Smith, Cambridge, GB;
Mark O'connor, Cambridge, GB;
Alan Ashworth, London, GB;
Stephen Jackson, Cambridge, GB;
Niall Martin, Cambridge, GB;
Graeme Smith, Cambridge, GB;
Mark O'Connor, Cambridge, GB;
Kudos Pharmaceuticals Limited, Cambridge, GB;
The Institute of Cancer Research, London, GB;
Abstract
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.