The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 20, 2012

Filed:

Jul. 06, 2009
Applicants:

LI Chen, Shanghai, CN;

Fariborz Firooznia, Florham Park, NJ (US);

Paul Gillespie, Westfield, NJ (US);

Yun He, Shanghai, CN;

Tai-an Lin, Pequannock, NJ (US);

Sung-sau SO, Nutley, NJ (US);

Hongying Yun, Shanghai, CN;

Zhenshan Zhang, Shanghai, CN;

Inventors:

Li Chen, Shanghai, CN;

Fariborz Firooznia, Florham Park, NJ (US);

Paul Gillespie, Westfield, NJ (US);

Yun He, Shanghai, CN;

Tai-An Lin, Pequannock, NJ (US);

Sung-Sau So, Nutley, NJ (US);

HongYing Yun, Shanghai, CN;

Zhenshan Zhang, Shanghai, CN;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/416 (2006.01); C07D 231/54 (2006.01); C07D 401/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R-Rand n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.


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