The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2012
Filed:
Feb. 02, 2009
Gil-ja Jhon, Seoul, KR;
Jin-kyung Limb, Seoul, KR;
Yun Soo Bae, Gyeonggi-do, KR;
Jae Sang Kim, Seoul, KR;
Gyoon Hee Han, Gyeonggi-do, KR;
So-yeop Han, Seoul, KR;
Gil-Ja Jhon, Seoul, KR;
Jin-Kyung Limb, Seoul, KR;
Yun Soo Bae, Gyeonggi-do, KR;
Jae Sang Kim, Seoul, KR;
Gyoon Hee Han, Gyeonggi-do, KR;
So-Yeop Han, Seoul, KR;
Abstract
The present invention relates to a method for inducing the differentiation of CD34+ hematopoietic stem cells into megakaryocytes and platelets, more particularly, a method for inducing the differentiation of CD34+ hematopoietic stem cells into megakaryocytes and platelets comprising the steps of coculturing CD34+ hematopoietic stem cells with stromal cells and adding the compound of Formula 1. Further, the present invention relates to a composition for detecting the differentiation of hematopoietic stem cells into megakaryocytes and platelets, comprising an agent measuring expression level of a gene that is selected from the group consisting of KLF2 (Kiruppel-like factor2), LOC138255 (OTTHUMP00000021439), GDF15 (growth differentiation factor 15) and INHBE (inhibin, betaE), a kit comprising the composition, a method for detecting the differentiation into megakaryocytes and platelets by using the marker genes, a method for regulating the differentiation into megakaryocytes and platelets, and a method for screening a candidate compound that regulates the differentiation into megakaryocytes and platelets.